Case report shows isotretinoin leads to myopathy with normal CK levels, emphasizing the importance of EMG for diagnosis.
Isotretinoin can cause toxic myopathy even at low doses with normal CK levels; proximal muscle weakness may be the only sign. EMG is essential for diagnosis, emphasizing the need for clinical vigilance and personalized assessment in patients with unexplained muscle symptoms on isotretinoin.
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Mahyar et al. (2025) studied this question.
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