Sirtuin 1 in osteoarthritis: Perspectives on regulating glucose metabolism

Zhihao Liao; Xuepei Cai; Yifan Zheng; Jiayu Lin; Xia Yang; Weiyin Lin; Ying Zhang; Xin He; Chufeng Liu

doi:10.1016/j.phrs.2024.107141

March 14, 2024Pharmacological ResearchOpen Access

Sirtuin 1 in osteoarthritis: Perspectives on regulating glucose metabolism

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Key Points

Excessive glycolytic activity in chondrocytes compromises mitochondrial respiration under pathological stimulation, inducing cartilage degeneration via inflammatory reprogramming.
Narrative assessment indicates that chondrocytes rely primarily on glycolytic capacity, exhibiting distinct spatiotemporal differences within low-oxygen articular cartilage.
Highlights the therapeutic potential of sirtuin 1 in modulating glucose metabolism, although targeted clinical strategies for managing osteoarthritis require further development.

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Implication

Narrative review reveals glucose metabolism dysregulation in articular chondrocytes, highlighting sirtuin 1 as a key therapeutic target for cartilage preservation.

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Cite This Study

Liao et al. (2024) studied this question.

synapsesocial.com/papers/68e73fdcb6db6435876b9734 https://doi.org/10.1016/j.phrs.2024.107141

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Sirtuin 1 in osteoarthritis: Perspectives on regulating glucose metabolism

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Sirtuin 1 in osteoarthritis: Perspectives on regulating glucose metabolism

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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