Use of a self-assembling peptide to control complications associated with endoscopic balloon dilation of refractory anastomotic stricture

PuraStat (3-D Matrix, Tokyo, Japan) is a novel self-assembling peptide hydrogel developed as a hemostatic agent that is believed to be effective in reducing the risk of delayed perforation due to excessive cautery burns [1] [2] [3]. Additionally, studies in animal models have suggested the potential of PuraStat for preventing esophageal strictures after endoscopic submucosal dissection for esophageal cancer [4] [5]. In this report, we present a case in which the self-assembling peptide gel effectively managed esophageal stricture and safely addressed complications related to endoscopic balloon dilation (EBD) ([Video 1]).