Endoscopic application of a self-assembling peptide hemostatic gel shows effective control of gastrointestinal bleeding, indicating a new treatment option.
Endoscopic hemostasis of parapapillary diverticular hemorrhage is challenging due to poor visualization caused by blood pooling and difficulty with endoscope manipulation. There have been reports of cases that required interventional radiology or surgical treatment. Recently, a new self-assembling peptide hemostatic gel (PuraStat; 3-D Matrix Ltd., Tokyo, Japan) has become available for treatment of gastrointestinal bleeding [1] [2]. We report the first case of hemostasis achieved with PuraStat for a bleeding duodenal diverticulum.
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Ebisawa et al. (2025) studied this question.
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