Extramedullary involvement in a patient with CD7+ and CD56+ Acute Myeloid Leukemia (AML) and PICALM-MLLT10 fusion gene: A challenging diagnosis and treatment

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The PICALM-MLLT10 fusion gene, generated by t (10;11) (p12-13; q14-21) translocation, is a rare event, described in various hematologic malignancies. In 2022 ELN classification, PICALM-MLLT10 was identified as acute myeloid leukemia (AML) with other rare recurring translocations. Data on clinical characteristics of PICALM–MLLT10 AML patients are scarce and outcome remains very poor in most patients. We report a case of PICALM-MLLT10 AML with CD7, CD56 co-expression and extramedullary disease.