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This case examines the rare synchronous presence of plasma cell myeloma and acute myelomonocytic leukemia.

453 Synchronous IgH::CCND1-Positive Plasma Cell Myeloma and Poor-risk Acute Myelomonocytic Leukemia: A Rare Case of Dual Hematological Malignancy

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Case report highlights the diagnostic complexity and therapeutic challenges of simultaneous plasma cell myeloma and acute myelomonocytic leukemia.

This case examines the rare synchronous presence of plasma cell myeloma and acute myelomonocytic leukemia.
Case report of an 83-year-old male with flu-like symptoms and significant laboratory findings.
Bone marrow biopsy revealed dominant plasma cell presence and myeloid components.
Utilized targeted next-generation sequencing to identify mutations and confirm diagnosis.
Patient had marked leukocytosis with white blood cell count of 48.97 x 10^9/L and 28.5% monocytosis.
Pathological findings confirmed plasma cell myeloma with Cyclin D1 expression and kappa light chain restriction.
Combination therapy with decitabine and venetoclax led to a decline in myeloma markers.

Nwanguma et al. (2025) studied this question.

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Case report highlights the diagnostic complexity and therapeutic challenges of simultaneous plasma cell myeloma and acute myelomonocytic leukemia.