What question did this study set out to answer?

To describe a rare case of simultaneous chronic myelomonocytic leukemia and multiple myeloma in a treatment-naïve patient.

Synchronous Presentation of Chronic Myelomonocytic Leukemia and Multiple Myeloma in a Treatment‐Naïve Patient

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Case presentation reports a rare concurrent malignancy, indicating complex management challenges.

To describe a rare case of simultaneous chronic myelomonocytic leukemia and multiple myeloma in a treatment-naïve patient.
Case presentation of a 42-year-old male with progressive fatigue and leukocytosis.
Laboratory evaluations including bone marrow examination, flow cytometry, and cytogenetic analysis.
Assessment of symptomatic multiple myeloma through imaging and serum protein electrophoresis.
Patient presented with marked absolute monocytosis (16.4 × 10 9 /L), anemia, and neutropenia.
Bone marrow biopsy showed 10%-15% plasma cells, confirming multiple myeloma alongside CMML.
Monosomy 7 was identified in cytogenetic analysis, supporting the diagnosis of clonal myeloid neoplasm.

Sweileh et al. (2026) studied this question.

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