Ivermectin Treatment for Strongyloides stercoralis– Associated Recurrence of Nongastric MALT Lymphoma

A healthy 64‐year‐old male originally from Peru presented with fever and abdominal pain and was successfully treated for Campylobacter colitis. An interval colonoscopy revealed mucosa‐associated lymphoid tissue (MALT) lymphoma initially in remission after four doses of rituximab and radiation with 24 Gy in 12 fractions. Two years after treatment, his symptoms returned, with a workup revealing recurrence of his MALT lymphoma. Biopsies revealed an underlying duodenal Strongyloides infection. In lieu of systemic chemotherapy, the patient was treated with oral ivermectin, which resulted in a complete response. MALT lymphoma is an indolent malignancy that can respond to treatment of an underlying infectious cause, and clinicians should be mindful of broad infectious etiologies, especially in immigrant populations.