What question did this study set out to answer?

To illustrate the diagnostic challenges of NPM1-mutated acute myeloid leukemia presenting with features of acute promyelocytic leukemia.

NPM1-Mutated Acute Myeloid Leukemia with Uterine Myeloid Sarcoma: A Diagnostic Challenge

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Case report highlights diagnostic uncertainty in acute myeloid leukemia with coagulopathy, implicating immunophenotyping and molecular testing.

To illustrate the diagnostic challenges of NPM1-mutated acute myeloid leukemia presenting with features of acute promyelocytic leukemia.
Case report of a 56-year-old patient presenting with severe hemorrhagic syndrome and leukocytosis.
Peripheral blood smear and immunophenotyping were used to assess leukemic cells.
Molecular testing confirmed NPM1 mutation while identifying extramedullary myeloid sarcoma.
Increased white blood cell count and specific immunophenotype indicated acute myeloid leukemia.
Presence of disseminated intravascular coagulation added diagnostic complexity.
Diagnostic features often overlap with those of acute promyelocytic leukemia, causing uncertainty.

TUNARU et al. (2026) studied this question.

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Case report highlights diagnostic uncertainty in acute myeloid leukemia with coagulopathy, implicating immunophenotyping and molecular testing.