What question did this study set out to answer?

To highlight an unusual presentation of acute promyelocytic leukemia (APL) masquerading as metastatic disease with bone lesions.

498 Bone Lesions as the First Clue: An Unusual Presentation of Acute Promyelocytic Leukemia

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Case report reveals atypical bone lesions in acute promyelocytic leukemia, indicating diagnostic challenges for timely treatment.

To highlight an unusual presentation of acute promyelocytic leukemia (APL) masquerading as metastatic disease with bone lesions.
Case report of a 72-year-old female with imaging findings suggesting metastatic disease.
Underwent imaging studies, immunohistochemistry, and multiple bone biopsies.
Flow cytometry and FISH analysis were performed for definitive diagnosis.
Immunohistochemistry showed positive markers CD33 and CD43 in bone biopsy.
FISH confirmed t(15;17) PML-RARA translocation in 92% of cells, verifying APL diagnosis.
Presentation of APL as bone lesions complicated timely treatment initiation.

Choe et al. (2025) studied this question.

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