What question did this study set out to answer?

To investigate the prevalence and implications of extramedullary manifestations in acute promyelocytic leukaemia at initial diagnosis.

Extramedullary manifestations of acute promyelocytic leukaemia at initial diagnosis: an autopsy analysis

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Autopsy analysis uncovers extramedullary disease in a young female with acute promyelocytic leukaemia, suggesting critical diagnostic challenges.

To investigate the prevalence and implications of extramedullary manifestations in acute promyelocytic leukaemia at initial diagnosis.
Case report of a young female patient with microgranular variant APL.
Postmortem examination to assess the extent of extramedullary disease.
Literature review of cases with extramedullary involvement in APL.
Postmortem findings revealed extensive leukaemic infiltration in liver, heart, brain, and meninges.
Patient experienced rapid clinical deterioration despite treatment with all-trans retinoic acid and arsenic trioxide.
Extramedullary involvement in APL was confirmed as rare but significant, particularly in the CNS.

S et al. (2026) studied this question.

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Autopsy analysis uncovers extramedullary disease in a young female with acute promyelocytic leukaemia, suggesting critical diagnostic challenges.