What question did this study set out to answer?

To investigate the immunophenotypic profile of NPM1-mutated acute myeloid leukemia and its correlation with vascular complications.

April 19, 2026HemaSphereOpen Access

APL‐like subset within NPM1 ‐mutated AML: A distinct immunophenotype correlating with early vascular complications

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Authors

FMFrancesco MannelliAzienda Ospedaliero-Universitaria Careggi FCFrancesca CrupiAzienda Ospedaliero-Universitaria Careggi SBSara BenciniAzienda Ospedaliero-Universitaria Careggi

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Implication

Retrospective analysis identifies APL-like immunophenotype correlating with early vascular events in NPM1-mut AML patients, implying tailored clinical measures are needed.

Key Points

To investigate the immunophenotypic profile of NPM1-mutated acute myeloid leukemia and its correlation with vascular complications.
Conducted a retrospective multicenter analysis of 384 NPM1-mut AML patients.
Identified 95 cases (24.7%) with an APL-like immunophenotype.
Analyzed coagulopathy markers and cumulative incidence of vascular events.
Validated findings in an independent cohort of 302 NPM1-mut patients enrolled in AMLSG 09-09 clinical trial.
Higher cumulative incidence of vascular events in APL-like group (30.5% vs. 10.1%).
Increased early death due to vascular complications in APL-like group (6.3% vs. 0.35%).
APL-like phenotype linked to higher frequency of IDH1/2 mutations (68.3% vs. 18.3%).
No influence on mortality in the validation cohort due to patient selection.

Cite This Study

Mannelli et al. (2026) studied this question.

synapsesocial.com/papers/69e472d8010ef96374d8eccf https://doi.org/10.1002/hem3.70307

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Implication

Retrospective analysis identifies APL-like immunophenotype correlating with early vascular events in NPM1-mut AML patients, implying tailored clinical measures are needed.

APL‐like subset within NPM1 ‐mutated AML: A distinct immunophenotype correlating with early vascular complications

Discussion

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Implication

Key Points

Cite This Study

APL‐like subset within NPM1 ‐mutated AML: A distinct immunophenotype correlating with early vascular complications

Discussion

Member takes

Implication

Key Points

Cite This Study

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