Supplemental Table 4 from Impact of Tumor-intrinsic Molecular Features on Survival and Acquired Tyrosine Kinase Inhibitor Resistance in ALK-positive NSCLC

Association of specific co-alterations with presence of ALK resistance mutations and variant type in EML-4-ALK samples (n=1118). Co-alterations of interest were (A) TP53 mutation, (B) PIK3CA mutation, (C) Wnt/B-catenin/PIK3CA pathway mutations [APC, CTNNB1, PIK3CA], (D) MET or MYC amplifications, and (E) cell cycle loss of function alterations [CDK4/6 or CDK2NA/B loss or loss of function mutations]. P-value is derived from Fisher's test. Significance at the level of p < 0.05 is indicated by the asterisk (*). Abbreviations: WT, wild-type.