Pediatric inflammatory multisystem syndrome in a patient with Hodgkin lymphoma: A case report

Hodgkin lymphoma is a lymphoid neoplasm that frequently presents in the pediatric population with enlarged lymph nodes and fever. The inflammatory state of this type of lymphoma can generate increases in inflammatory markers that can sometimes be attributed to an infection in these immunosuppressed patients. During the COVID-19 pandemic, the diagnosis and treatment of patients with hematological malignancies was complicated by the presence of SARS-CoV2, which could range from an asymptomatic presentation to a multisystem inflammatory syndrome known as the Pediatric inflammatory multisystem syndrome (PIMS). We present the case of a girl who, during the COVID-19 pandemic, was treated at our institution due to increased lymph node volume and persistent fever. The febrile syndrome was attributed to intercurrent infection; however, despite antimicrobial coverage, fever persisted, and inflammatory markers increased. Although SARS-CoV2 was not detected in the samples, PIMS was clinically suspected, so treatment with human immunoglobulin and acetylsalicylic acid was started and an improvement in the inflammatory parameters was evidenced, which allowed ruling out any opportunistic infection and initiating the corresponding chemotherapy treatment.