Why the study?
Patterns of treatment-related cardiac dysfunction in children with acute myeloid leukemia were not well characterized over multiple chemotherapy cycles.
Observational
No
AST, ANC, and hemoglobin independently predict severe toxicity during high-dose methotrexate therapy in high-risk pediatric patients, enabling targeted individualized monitoring.
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Karthik et al. (2026) conducted an observational in Acute Myeloid Leukemia. High-dose methotrexate (HDMTX) therapy was evaluated on Severe toxicity.
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