What question did this study set out to answer?

This research investigates the incidence and predictors of high-dose methotrexate (HDMTX)-related toxicities in pediatric acute lymphoblastic leukemia (ALL).

July 15, 2026Indian Journal of Medical and Paediatric OncologyOpen Access

High-Dose Methotrexate-Associated Toxicity in Pediatric Acute Lymphoblastic Leukemia: A Prospective Cohort Study from a Resource-Limited Setting

View Full Paper

Ask AI

Bookmark

This research investigates the incidence and predictors of high-dose methotrexate (HDMTX)-related toxicities in pediatric acute lymphoblastic leukemia (ALL).
Conducted a prospective cohort study over 18 months with 40 children aged 1-12 years receiving HDMTX.
Analyzed 138 HDMTX cycles and assessed toxicities using the CTCAE v5.0 criteria.
Performed multivariate logistic regression to evaluate risk factors at the cycle level.
Anemia was the most common hematological toxicity (94.9%), followed by thrombocytopenia (31.9%) and febrile neutropenia (23.2%).
Hepatotoxicity occurred in 89.1% of cycles, while renal toxicity was infrequent (1.4%).
T-cell immunophenotype predicted febrile neutropenia (adjusted OR 2.84; p = 0.018) and mucositis (adjusted OR 3.21; p = 0.006).

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Prospective cohort study explores HDMTX-related toxicities in children with ALL, suggesting improved monitoring strategies.

Cite This Study

Jha et al. (2026) studied this question.

synapsesocial.com/papers/6a5722f088b21df87547fcf4 https://doi.org/10.1055/s-0046-1825562

View Full Paper

Ask AI

Bookmark

High-Dose Methotrexate-Associated Toxicity in Pediatric Acute Lymphoblastic Leukemia: A Prospective Cohort Study from a Resource-Limited Setting

Key Points

Discussion

Implication

Cite This Study

High-Dose Methotrexate-Associated Toxicity in Pediatric Acute Lymphoblastic Leukemia: A Prospective Cohort Study from a Resource-Limited Setting

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider