Revisiting predictors of high-dose methotrexate related severe nephrotoxicity in children with acute lymphoblastic leukemia

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Nephrotoxicity occurred in 37.7% of children receiving HDMTX, indicating significant risk.
Concurrent use of amikacin had an adjusted odds ratio of 17.693, revealing a major risk factor.
Retrospective review of 61 children with ALL receiving high-dose methotrexate therapy.
Identifying predictors assists in preventing nephrotoxicity, highlighting clinical care implications.

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Retrospective analysis shows amikacin and urine pH predict nephrotoxicity in children with ALL, suggesting preventative factors.

Khorana et al. (2025) studied this question.

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