Hepatotoxic Effects of High-Dose Methotrexate in Children with Acute Lymphoblastic Leukemia: Patterns, Recovery, and Clinical Implications

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Prospective analysis reveals HDMTX-related hepatotoxicity in children, indicating the need for liver monitoring and support.

HDMTX causes transient hepatotoxicity, with 70% showing elevated liver enzymes post-treatment, and recovery achieved in most cases.
Baseline liver function tests were mostly normal, with notable increases in ALT and bilirubin after HDMTX treatment.
Prospective study focused on liver function changes throughout chemotherapy phases in pediatric acute lymphoblastic leukemia.
Regular monitoring and supportive care are crucial in managing drug-induced liver injury, especially in low-resource settings.

Rahman et al. (2020) studied this question.

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