Impact of Induction Chemotherapy on Liver Function in Pediatric Acute Lymphoblastic Leukemia (ALL): A Clinical Analysis

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Induction chemotherapy transiently elevated liver function tests in children with acute lymphoblastic leukemia during treatment phases.
Among 30 children with ALL, serum bilirubin rose from 6.7% to 16.7% post-chemotherapy, while elevated ALT increased from 20% to 30%.
The assessment involved monitoring liver function tests before and after induction chemotherapy and during maintenance therapy in a prospective study design.
Continued observation is essential as most liver parameters normalized but indicate significant hepatotoxicity risks during treatment phases.

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Prospective study finds elevated serum bilirubin and transaminases in children with ALL undergoing chemotherapy, indicating potential hepatotoxicity.

Rahman et al. (2018) studied this question.

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Prospective study finds elevated serum bilirubin and transaminases in children with ALL undergoing chemotherapy, indicating potential hepatotoxicity.