Comprehensive evaluation of high dose methotrexate therapy: a retrospective observational trial

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Retrospective cohort study assesses 48-h serum MTX levels and toxicity in cancer patients, indicating significant risks.

Elevated 48-h MTX levels are linked to increased antimicrobial use and specific patient diagnoses, impacting treatment protocols.
Findings show that patients with elevated serum MTX levels experience more complications, including pleural effusion and specific drug use.
The study used data from 143 patients undergoing treatment to evaluate relationships between MTX levels and adverse effects.
Monitoring 48-h MTX levels is critical for managing toxicity, hospital length of stay, and overall mortality rates.

Barakat et al. (2025) studied this question.

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