What question did this study set out to answer?

This research aims to assess the relationship between methotrexate and 7-hydroxymethotrexate levels and liver and kidney function indicators.

Prediction of Clinical Safety for High-Dose Methotrexate Chemotherapy Based on Free Levels of Methotrexate and 7-Hydroxymethotrexate in Human Plasma

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Evaluates methotrexate levels in predicting kidney and liver safety in leukemia and lymphoma patients, indicating important clinical implications.

This research aims to assess the relationship between methotrexate and 7-hydroxymethotrexate levels and liver and kidney function indicators.
Collected 372 blood samples from 107 leukemia or lymphoma patients treated with high-dose methotrexate
Measured free and total concentrations of methotrexate and 7-hydroxymethotrexate
Used SPSS 27 for Spearman correlation analysis between drug concentration and organ function indicators
Employed the Mann–Whitney U test for comparison between Normal and Delayed elimination groups
Conducted receiver operating characteristic curve analysis for threshold identification
Free 7-hydroxymethotrexate concentrations significantly correlated with creatinine clearance and creatinine in children
Alanine aminotransferase and aspartate aminotransferase were negatively correlated with 7-hydroxymethotrexate and methotrexate levels in children
No significant correlations were found in adult patients regarding drug concentrations and organ function

Gao et al. (2026) studied this question.

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Evaluates methotrexate levels in predicting kidney and liver safety in leukemia and lymphoma patients, indicating important clinical implications.