March 13, 2024Aging CellOpen Access

The aged microenvironment impairs BCL6 and CD40L induction in CD4+ T follicular helper cell differentiation

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Authors

JFJacob S. FisherMayo Clinic Hospital IAIrene Adán‐BarrientosInstituto de Salud Carlos III NKNaveen KumarAgency for Science, Technology and Research

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Implication

Preclinical murine study demonstrates aged lymphoid microenvironments impair CD4+ T cell differentiation in mice, highlighting cell-extrinsic drivers of weakened germinal center responses.

Key Points

Aged lymphoid environments suppress BCL6 and CD40L induction during CD4+ T cell differentiation, impairing germinal center formation and antibody production.
Adoptive transfer of young CD4+ T cells into aged mice revealed diminished T follicular helper cells expansion and reduced CD40L with elevated CD39 expression.
These findings show aged microenvironments impair germinal center responses through extrinsic signals, though mechanisms require validation beyond this mouse model.

Cite This Study

Fisher et al. (2024) studied this question.

synapsesocial.com/papers/68e74345b6db6435876bc461 https://doi.org/10.1111/acel.14140

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Implication

Preclinical murine study demonstrates aged lymphoid microenvironments impair CD4+ T cell differentiation in mice, highlighting cell-extrinsic drivers of weakened germinal center responses.

The aged microenvironment impairs BCL6 and CD40L induction in CD4+ T follicular helper cell differentiation

Discussion

Member takes

Implication

Key Points

Cite This Study

The aged microenvironment impairs BCL6 and CD40L induction in CD4+ T follicular helper cell differentiation

Discussion

Member takes

Implication

Key Points

Cite This Study

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