In this presentation, I will describe our efforts to design and build small molecule probes that can be used to identify, inhibit and image various hydrolytic enzyme targets in models of cancer and infectious disease. This will include recent advances in protease activated fluorescent probes for real-time visualization of tumors during surgery as well our efforts to identify several and image new classes of serine hydrolases in pathogenic and commensal bacteria.
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Matthew Bogyo (2024) studied this question.
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