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Confocal fluorescence microscopy is a common imaging technique for biomedical applications such as tumor characterization, precision resections, etc... However, the imaging process is limited by photo bleaching of samples and optical scattering limits imposed by wavelength limitations of traditionally used detection technologies. Here we show that by leveraging the high detection efficiency and large spectral range of superconducting nanowire single-photon detectors, it is possible to image deeper into tissue with a significant reduction in laser excitation power compared to the same technique using silicon photo-multipliers.
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Rambo et al. (2024) studied this question.
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