In vivo imaging demonstrates cortical blood perfusion dynamics after photothrombotic stroke in mice, indicating expanded capacity for longitudinal cerebrovascular monitoring.
High-resolution optical imaging is accompanied by a limited depth of field, making it challenging to obtain non-stitched, high-resolution images of samples with uneven surfaces without performing Z-axis scanning. To solve this problem, we introduced diffractive optical elements into the conventional OCT system and develop a needle-shaped beam OCT system with both long DOF and high resolution, which maintains 8μm lateral resolution over a depth range of 620μm. The system was then employed to perform a 10-day cortical blood perfusion observation after stroke, providing visual and mechanistic insight into stroke, deepening our understanding of the brain response after stroke.
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Guo et al. (2024) studied this question.
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