This research introduces a new approach based on Raman spectroscopy for quickly and effectively detecting brain tumors at a macroscopic scale, making it suitable for intra-operative use. By focusing on a specific vibrational band at 1440 cm-1 as a cancer biomarker, this method will enable rapid imaging of a field of view spanning several centimeters in approximately 5 seconds. The results of this study demonstrated high sensitivity/specificity for meningioma (97%/95%), brain metastases (95%/91%), and glioblastoma (78%/84%). The performance of this developed imaging system was compared to a custom hyperspectral line-scanning Raman system as the gold standard.
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Leblond et al. (2024) studied this question.
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