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March 13, 2024Reports of Practical Oncology & RadiotherapyOpen Access

Determination of dose-response calibration curves for gamma radiation using gamma-H2AX immunofluorescence based biodosimetry

Solomon Raj Jose Peace Balasingh Timothy J. Suganthy Selvamani Backianathan Soosai Manickam Amirtham Sandya Rani Rabi Raja Singh

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Abstract

Gamma-H2AX immunofluorescence assay has gained popularity as a DNA double strand break marker. In this work, we have investigated the potential use of gamma H2AX immunofluorescence assay as a biological dosimeter for estimation of dose in our institution.

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Cite This Study

Jose et al. (2024) studied this question.

synapsesocial.com/papers/68e74464b6db6435876be262 https://doi.org/10.5603/rpor.99678

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Application of an imaging flow cytometry γ-H2AX assay for biodosimetry using supervised machine learning.2025 · 4 citations
2Considerations for the Use of the DNA Damage Marker γ‐H2AX in Disease Modeling, Detection, Diagnosis, and Prognosis2024 · 6 citations
3Quantitative analysis of γ-H2AX foci kinetics: differential DNA damage response between primary PBMCs and HEp-2 tumor cells following gamma-irradiationIn Vitro Study · 2025
4Temporal and spatial patterns of γH2AX signaling in different human cells after exposure to X-rays and UV-C lightOriginal Research · 2026
5Detection and quantification of γ-H2AX using a dissociation enhanced lanthanide fluorescence immunoassayOriginal Research · 2021 · 46 citations

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