Development of novel hologram-based sensors for patient dosimetry in daylight photodynamic therapy (D-PDT)

Here, a holographic sensor technology capable of measuring the dose received at the patient treatment site during daylight photodynamic therapy (D-PDT) is presented. The proposed transmission-mode holographic sensor enables more precise, customized dosimetry, with the objective of quantifying the weighted PPIX dose a patient receives, facilitating the potential for further optimization of therapies. The experimental development and optimization of the photosensitive film-based holographic sensor for D-PDT dosimetry is described. Both the photosensitive film fabrication process and the two-beam interferometric recording of holographic gratings have been optimized. Preliminary findings support the suitability of holographic gratings for D-PDT dosimetry.