Assessment of the potential habitat suitability and ephedrine quality of two Ephedra species in China under climate change

Ephedra sinica and Ephedra intermedia are important medicinal plants and critical raw materials for ephedrine extraction in the pharmaceutical industry. Climate change will affect their distribution and quality. In our study, information on E. sinica and E. intermedia was collected through wilderness and online surveys. Using high-performance liquid chromatography, we determined the contents of ephedrine and pseudoephedrine. We then utilized the maximum entropy model to assess the potential impact of future climate on the distribution and quality of the two Ephedra. The results showed that the two Ephedra species were predominantly found in the arid and semiarid regions of northern China. The suitable habitats and quality area of E. intermedia will be severely degraded under RCP 2.6, RCP 4.5 and RCP 8.5 conditions and the results for E. sinica are the opposite. The accumulation of chemical components in E. sinica depends on the precipitation of the wettest month (Bio13) and soil sand content, while the accumulation of chemical components in E. intermedia depends on the mean temperature of the warmest quarter (Bio10) and the precipitation seasonality (Bio15). Overall, the research results provide the basis for the two high-quality Ephedra species for conservation and sustainable resource development.