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March 12, 2024Bone Marrow TransplantationOpen Access

Long term outcomes of nonmyeloablative allogeneic stem cell transplantation with TSEB TLI and ATG for Mycosis Fungoides and Sezary Syndrome

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Authors

SMStephen MorrisGuy's HospitalBTB. ThomasGuy's HospitalRPRenuka PalanicawandarHammersmith Hospital

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Implication

Prospective cohort study shows durable survival after nonmyeloablative stem cell transplant in mycosis fungoides and Sezary syndrome, indicating pretransplant complete response optimizes outcomes.

Key Points

  • Long term survival is achievable in advanced mycosis fungoides and sezary syndrome using nonmyeloablative allogeneic stem cell transplantation with total skin electron beam therapy.
  • A five-year overall survival rate of 37.7% was achieved, while disease relapse dropped to 20.8% in mycosis fungoides patients entering transplantation in complete response.
  • Prospective cohort analysis highlights that total lymphoid irradiation conditioning combined with antithymocyte globulin yields durable disease control when preceded by complete remission.

Cite This Study

Morris et al. (2024) studied this question.

synapsesocial.com/papers/68e745afb6db6435876bebb9https://doi.org/10.1038/s41409-024-02236-z
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Increased Programmed Death-1 Expression on CD4+ T Cells in Cutaneous T-Cell Lymphoma2010 · 139 citations
  2. 2Nonmyeloablative allogeneic transplantation achieves clinical and molecular remission in cutaneous T-cell lymphoma2020 · 49 citations
  3. 3Total Skin Electron Beam and Non-Myeloablative Allogeneic Hematopoietic Stem-Cell Transplantation in Advanced Mycosis Fungoides and Sézary Syndrome2010 · 168 citations
  4. 4Clinical End Points and Response Criteria in Mycosis Fungoides and Sézary Syndrome: A Consensus Statement of the International Society for Cutaneous Lymphomas, the United States Cutaneous Lymphoma Consortium, and the Cutaneous Lymphoma Task Force of the European Organisation for Research and Treatment of Cancer2011 · 670 citations
  5. 5Survival Outcomes and Prognostic Factors in Mycosis Fungoides/Sézary Syndrome: Validation of the Revised International Society for Cutaneous Lymphomas/European Organisation for Research and Treatment of Cancer Staging Proposal2010 · 856 citations