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March 12, 2024MoleculesOpen Access

One-Step Construction of 1,3,4-Oxadiazoles with Anticancer Activity from Tertiary Amines via a Sequential Copper(I)-Catalyzed Oxidative Ugi/aza-Wittig Reaction

Mei Sun Nong‐Qi Mao Sheng-Long Wang Xin-Ming Han Gang Yao Ping Xue Chongyang Zeng Yuting Liu Kai Chen Xiaoqing Gao Jun Xiong

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Abstract

An unparalleled copper(I)-catalyzed synthesis of 1,3,4-oxadiazoles from tertiary amines in one step has been described. The one-pot reactions involving (N-isocyanimine)triphenylphosphorane, tertiary amines, and carboxylic acids resulted in the formation of 1,3,4-oxadiazoles in moderate to good yields through a consecutive oxidative Ugi/aza-Wittig reaction, enabling the direct functionalization of sp

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Cite This Study

Sun et al. (2024) studied this question.

synapsesocial.com/papers/68e745c5b6db6435876bf504 https://doi.org/10.3390/molecules29061253

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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