Acute vasculature disruption in orthotopic kidney tumors based on vascular disrupting agent (OXi8007) examined by multispectral optoacoustic tomography (MSOT)

Multispectral optoacoustic tomography (MSOT) provides anatomical and functional imaging of tissues without the need for reporter molecules or transfection. We examined the acute vascular disrupting activity of a new microtubule disrupting agent (OXi8007) using MSOT on syngeneic mouse RENCA-luc, and human XP258 orthotopic kidney tumors. In both tumor types, an oxygen gas breathing challenge showed reduced tumor oxygenation and response within 4h of treatment. In RENCA-luc tumors this matched vascular shutdown assessed by dynamic BLI. MSOT additionally confirmed that VDA did not significantly affect the contralateral normal kidney or spine.