Corneal collagen crosslinking (CXL) is a surgical procedure to treat corneal ectasia. Ultraviolet (UV) light and riboflavin are combined to modify corneal microstructure by forming additional chemical bounds between stromal collagen fibers. Because of limited in-depth penetration of riboflavin and UV-light attenuation, a demarcation between treated and untreated regions can be observed, suggesting a two-layer structure after treatment. Here, we present a method of elastic moduli reconstruction in both cornea layers using OCE-tracked guided waves and an analytical model of a 2-layer nearly incompressible transversely isotropic (NITI) medium. An example of reconstruction is demonstrated in an ex vivo human cornea.
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Pelivanov et al. (2024) studied this question.
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