The latest innovations in label-free virtual-histology using Photon Absorption Remote Sensing (PARS) are presented. PARS captures endogenous absorption (radiative and non-radiative) and scattering contrasts, enabling label-free biomolecule specific imaging. Combined with innovations in AI and signal processing, PARS provides several label-free virtual histochemical stains (e.g., H&E, T-blue) directly from a single scan of an unprocessed tissue specimen. Results validated through clinical efficacy studies indicate that PARS virtual staining is diagnostically indistinguishable from gold standard chemical histology. This represents a crucial milestone in deploying PARS as an alternative to standard histopathology.
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Ecclestone et al. (2024) studied this question.
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