Photoacoustic-Brillouin multimodal imaging modality

In this work, we developed a new multimodal technology that can simultaneously measure a subset of mechanical, optical, and acoustical properties of the sample, which is based on the integration of Brillouin and photoacoustic (PA) microscopy. Notably, this integration offers a novel approach to probing the refractive index of the sample, which is inaccessible through each technique alone. As a proof-of-concept, we demonstrated the feasibility of the combined setup to obtain the co-registered Brillouin and time-resolved PA signals in a synthetic phantom made of kerosene and CuSO4 aqueous solution. In addition, we measured the refractive index of saline solutions and validated the result in comparison with previously reported data.