March 12, 2024Open Access

Cooperative colonization of the host and pathogen dissemination involves stochastic and spatially structured expression of virulence traits

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Authors

NLNieves López‐PagánConsejo Superior de Investigaciones Científicas JRJosé S. RufiánConsejo Superior de Investigaciones Científicas JLJulien LuneauUniversity of Lausanne

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Implication

Single-cell analysis reveals division of labor through phenotypic heterogeneity in Pseudomonas syringae, highlighting cooperative host colonization and pathogen dissemination strategies.

Key Points

Phenotypic heterogeneity in Pseudomonas syringae drives a cooperative division of labor, enabling colonization through shared virulence traits despite high growth penalties.
Single-cell investigation reveals that type III secretion system effectors act as common goods to suppress host immunity, while flagellar expression promotes tissue escape.
These dynamics highlight how division of labor coordinates infection within host tissues; plant model findings warrant further validation across broader pathosystems.

Cite This Study

López‐Pagán et al. (2024) studied this question.

synapsesocial.com/papers/68e747e0b6db6435876c0b49 https://doi.org/10.1101/2024.03.12.584633

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March 12, 2024Open Access

Cooperative colonization of the host and pathogen dissemination involves stochastic and spatially structured expression of virulence traits

View Full Paper

Ask AI

Bookmark

Authors

NLNieves López‐PagánConsejo Superior de Investigaciones Científicas JRJosé S. RufiánConsejo Superior de Investigaciones Científicas JLJulien LuneauUniversity of Lausanne

Discussion

Member takes

Implication

Single-cell analysis reveals division of labor through phenotypic heterogeneity in Pseudomonas syringae, highlighting cooperative host colonization and pathogen dissemination strategies.

Key Points

Phenotypic heterogeneity in Pseudomonas syringae drives a cooperative division of labor, enabling colonization through shared virulence traits despite high growth penalties.
Single-cell investigation reveals that type III secretion system effectors act as common goods to suppress host immunity, while flagellar expression promotes tissue escape.
These dynamics highlight how division of labor coordinates infection within host tissues; plant model findings warrant further validation across broader pathosystems.

Cite This Study

López‐Pagán et al. (2024) studied this question.

synapsesocial.com/papers/68e747e0b6db6435876c0b49 https://doi.org/10.1101/2024.03.12.584633

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