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March 12, 2024Current Computer - Aided Drug Design

Design, Synthesis, Antitumor Activity Evaluation, and Molecular Dynamics Simulation of Some 2-Aminopyrazine Derivatives

Hangrui Cui Ruifeng Zhang Xin Xiong Zhiwen Cui Zhijian Min Jing-Long Liu Xunping Li Zhen-Li Min

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Abstract

Cancer poses a great threat to human health, and effective drugs to treat it are always needed. Several compounds containing a 2-aminopyrazine framework have been identified as antitumor agents with SHP2 inhibition activities. This current work aimed to search for more potent novel compounds possessing a 2-aminopyrazine moiety with antitumor activities.

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Cite This Study

Cui et al. (2024) studied this question.

synapsesocial.com/papers/68e747e6b6db6435876c0e9a https://doi.org/10.2174/0115734099285448240304072649

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