Synaptic dysfunction driven by toxic amyloid Aβ oligomers (Aβo) is one of the early events in Alzheimer's disease (AD) leading to cognitive decline, disability, and death. We have shown that optoacoustic therapy/NPLT can be used for traumatic brain injury (TBI) treatment. We have also shown that mature neurons generated from the NPLT-treated rat hippocampal neural stem cells (NSCs) had significantly lower Aβo levels. Here we used a custom-made 808-nm optoacoustic system to study autophagy pathways changes induced by NPLT. Our results suggest that autophagy pathways are upregulated in NPLT-treated NSCs compared to sham which could lead to enhanced Aβo clearance.
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Johnson et al. (2024) studied this question.
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