Comparison of Myo-Inositol Alone Versus in Combination With Clomiphene Citrate for Management of Females Presenting With Polycystic Ovarian Syndrome

Objectives: To compare the frequency of ovulation with myo-inositol alone versus in combination with clomiphene citrate for management of females presenting with polycystic ovarian syndrome. Materials and Methods: In this RCT study, we enrolled a total of 500 females. Then females were randomly divided into two groups by using the lottery method. In group A, females were given 2g of myoinositol before breakfast and in group B, females were given 2g of myoinositol plus clomiphene citrate 50mg tablet before breakfast for 12 weeks. Females were followed up for 12 weeks. Then females underwent color Doppler ultrasonography for assessment of ovulation. If follicle of size ≥21mm ovulate from ovary on ultrasound, then ovulation was labeled. All this information was recorded through pre-designed proforma. The collected data was analyzed statistically by using SPSS version 21. Results: In myoinositol group, the mean age of patients was 30.92±5.91years. In myoinositol plus clomiphene citrate group, the mean age of patients was 30.24±5.85years. After 4 weeks, ovulation was achieved in 39 (15.6%) patients with myoinositol and in 75 (30%) patients with myoinositol plus clomiphene citrate. After 8 weeks, ovulation was achieved in 119 (47.6%) patients with myoinositol and in 153 (61.2%) patients with myoinositol plus clomiphene citrate. After 12 weeks, ovulation was achieved in 154 (61.6%) patients with myoinositol and in 196 (78.4%) patients with myoinositol plus clomiphene citrate. The difference was significant (p<0.05). Conclusion: It was concluded that the combination of myoinositol and clomiphene citrate was more effective in ovulation in females with PCOS.