Synthesis of hydantoins from N‐Boc protected amino acid derived amides using polymer‐supported PPh₃/CBr₄ as a reagent

Hydantoin derivatives are versatile structural motifs found in natural products and various compounds with different biological or other properties. Due to their importance in both organic and medicinal chemistry, a number of synthetic procedures have been developed. In this article, a novel methodology utilizing N ‐Boc protected amino acid amides for their preparation has been described. The cyclisation process was accomplished using solid supported PPh 3 and CBr 4 as reagents affording substituted hydantoins in moderate to good yields (40%–77%).