March 7, 2024Annals of HepatologyOpen Access

Neurofilament light chain but not glial fibrillary acidic protein is a potential biomarker of overt hepatic encephalopathy in patients with cirrhosis

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KWKoos de WitLeiden University DDDiederick J. van DoornAmsterdam University Medical Centers BMBregje MolAmsterdam Neuroscience

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Prospective cohort study reveals elevated plasma neurofilament light chain in cirrhotic patients with overt hepatic encephalopathy, highlighting its utility as a diagnostic biomarker.

Key Points

Plasma neurofilament light chain levels rise significantly during overt hepatic encephalopathy, whereas glial fibrillary acidic protein concentrations show no specific change.
Significantly higher (p<0.05) plasma neurofilament light chain marked overt hepatic encephalopathy in intensive care, and concentrations correlated with MELD score (R=0.58).
Prospective cohort analysis of 85 patients using single molecule assays suggests plasma neurofilament light chain warrants evaluation as a biomarker for overt cerebral damage.

Cite This Study

Wit et al. (2024) studied this question.

synapsesocial.com/papers/68e75441b6db6435876ccbbc https://doi.org/10.1016/j.aohep.2024.101496

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Implication

Prospective cohort study reveals elevated plasma neurofilament light chain in cirrhotic patients with overt hepatic encephalopathy, highlighting its utility as a diagnostic biomarker.

Neurofilament light chain but not glial fibrillary acidic protein is a potential biomarker of overt hepatic encephalopathy in patients with cirrhosis

Discussion

Member takes

Implication

Key Points

Cite This Study

Neurofilament light chain but not glial fibrillary acidic protein is a potential biomarker of overt hepatic encephalopathy in patients with cirrhosis

Discussion

Member takes

Implication

Key Points

Cite This Study

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Also Consider