The antiretroviral drug tenofovir, is a nucleotide analogue which is used in the treatment of HIV and hepatitis B infections. This drug works by inhibiting the HIV reverse transcriptase enzyme and prevent the synthesis of viral DNA. It is administered as a single 300 mg tablet once daily. This drug is mostly used in the combination with lamivudine, dolutegravir (TLD regimen). Although there has been success in the use of tenofovir in treating HIV infection, there have been some adverse effects associated with it. Multiple studies have implicated tenofovir associated bone loss and renal failure. In order to treat the adverse effects which are caused due to tenofovir, an alternate drug should be administered.
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Dhomakonda et al. (2024) studied this question.
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