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March 6, 2024Statistical Methods in Medical Research

BOIN-ETC: A Bayesian optimal interval design considering efficacy and toxicity to identify the optimal dose combinations

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Authors

TKTomoyuki KakizumeDaiichi Sankyo (Germany)KTKentaro TakedaCenter for Global DevelopmentMTMasataka TaguriNihon University

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Kakizume et al. (2024) studied this question.

synapsesocial.com/papers/68e7579cb6db6435876ceceehttps://doi.org/10.1177/09622802241236936
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1TITE‐gBOIN‐ET: Time‐to‐event generalized Bayesian optimal interval design to accelerate dose‐finding accounting for ordinal graded efficacy and toxicity outcomes2023 · 19 citations
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  4. 4Incorporating historical information to improve dose optimization design with toxicity and efficacy endpoints: iBOIN‐ET2022 · 13 citations
  5. 5TITE‐BOIN12: A Bayesian phase I/II trial design to find the optimal biological dose with late‐onset toxicity and efficacy2022 · 60 citations