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March 6, 2024BMC Complementary Medicine and TherapiesOpen Access

Triptolide mitigates the inhibition of osteogenesis induced by TNF-α in human periodontal ligament stem cells via the p-IκBα/NF-κB signaling pathway: an in-vitro study

Hao Chen Lina Zhang Simeng Du Daiwei Yang Xiaobin Cui Huadong Zhao Jun Zhang

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Abstract

Triptolide is a widely utilized natural anti-inflammatory drug in clinical practice. Aim of this study was to evaluate effects of triptolide on hPDLSCs osteogenesis in an inflammatory setting and to investigate underlying mechanisms.

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Cite This Study

Chen et al. (2024) studied this question.

synapsesocial.com/papers/68e757a4b6db6435876cf0de https://doi.org/10.1186/s12906-024-04408-2

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Triptolide Attenuates Traumatic Heterotopic Ossification via Modulation of Inflammatory and Differentiation Pathways: Implications for Biochemical Toxicology2025 · 2 citations
2Triptolide attenuates lipopolysaccharide-induced inflammatory responses in human endothelial cells: involvement of NF-κB pathwaypreclinical · 2019 · 37 citations
3Timosaponin B- II Enhances Osteogenic Differentiation of Human Periodontal Ligament Stem Cells via PI3K/AKT/GSK3β Signaling Pathway2025 · 1 citations
4Triptolide Inhibits Renal Fibrosis Through Promotion of PGC1α/PCK1-mediated Renal GluconeogenesisOriginal Research · 2026 · 1 citations
5Immunosuppressive effects of triptolide via interleukin-2/receptor signaling2024 · 1 citations

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Anti-inflammatory effects of triptolide improve left ventricular function in a rat model of diabetic cardiomyopathy2013
Trifolirhizin reduces osteoclast formation and prevents inflammatory osteolysis by inhibiting RANKL‐induced activation of NF‐κB and MAPK signaling pathways and ROS2024
Triptolide Suppresses Tongue Squamous Cell Carcinoma Progression via PI3K – AKT Pathway Inhibition: An Integrative Network Pharmacology and Experimental Validation Study2026

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