Findings demonstrate that triptolide reduces renal fibrosis through enhanced gluconeogenesis in kidney cells, suggesting a new treatment approach.
Triptolide may inhibit renal fibrosis by increasing the PGC1α/PCK1 axis, thereby promoting renal gluconeogenesis. This cascade may reduce histone lactylation and renal inflammation, providing a mechanistic pathway for its anti-fibrotic effect.
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Wang et al. (2026) studied this question.
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