March 5, 2024Journal of Clinical InvestigationOpen Access

CD8+ T cells sustain antitumor response by mediating crosstalk between adenosine A2A receptor and glutathione/GPX4

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Authors

SCSiqi ChenGuangdong Pharmaceutical University JFJie FanNorthwestern University PXPing XieCapital Medical University

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Implication

Preclinical study reveals metabolic regulation of CD8+ T cells via adenosine and glutathione pathways, suggesting targets to prevent ferroptosis and enhance adoptive cell therapy.

Key Points

CD8+ T cells require balanced adenosine A2A receptor signaling and the glutathione-GPX4 axis to sustain metabolic fitness and survive against ferroptotic cell death.
Experimental dual inhibition of adenosine A2A receptor and lipid peroxidation ex vivo promotes robust proliferation and long-term in vivo survival of activated CD8+ T cells.
Profiling intratumoral CD8+ T cells links a glutathione gene signature with patient survival across cancers, highlighting adoptive cell therapy; further preclinical work needed.

Cite This Study

Chen et al. (2024) studied this question.

synapsesocial.com/papers/68e758bcb6db6435876d06a8 https://doi.org/10.1172/jci170071

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Implication

Preclinical study reveals metabolic regulation of CD8+ T cells via adenosine and glutathione pathways, suggesting targets to prevent ferroptosis and enhance adoptive cell therapy.

CD8+ T cells sustain antitumor response by mediating crosstalk between adenosine A2A receptor and glutathione/GPX4

Discussion

Member takes

Implication

Key Points

Cite This Study

CD8+ T cells sustain antitumor response by mediating crosstalk between adenosine A2A receptor and glutathione/GPX4

Discussion

Member takes

Implication

Key Points

Cite This Study

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