Discovery of RORγ Allosteric Fluorescent Probes and Their Application: Fluorescence Polarization, Screening, and Bioimaging

Yan‐Cheng Yu; Zhen‐Jiang Tong; Xiaoting Liang; Jiazhen Wu; Yujing Xu; Jingjing Wang; Mengyuan Zhang; Tian‐Hua Wei; Jin Yang; Yibo Wang; Qing-Xin Wang; Qingqing Li; Zixuan Wang; Xuejiao Leng; Ning Ding; Xin Xue; Shan‐Liang Sun; Nian‐Guang Li; Xiao-Long Wang

doi:10.1021/acs.jmedchem.4c00058

Abstract

Retinoic acid receptor-related orphan receptor γ (RORγ) acts as a crucial transcription factor in Th17 cells and is involved in diverse autoimmune disorders. RORγ allosteric inhibitors have gained significant research focus as a novel strategy to inhibit RORγ transcriptional activity. Leveraging the high affinity and selectivity of RORγ allosteric inhibitor

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Yu et al. (2024) studied this question.

synapsesocial.com/papers/68e75a12b6db6435876d1883 https://doi.org/10.1021/acs.jmedchem.4c00058

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Discovery of RORγ Allosteric Fluorescent Probes and Their Application: Fluorescence Polarization, Screening, and Bioimaging

Abstract

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Cite This Study

Discovery of RORγ Allosteric Fluorescent Probes and Their Application: Fluorescence Polarization, Screening, and Bioimaging

Abstract

Discussion

Cite This Study

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