High-Grade Metastatic Pleomorphic Rhabdomyosarcoma in a TP53 Germline Mutation Patient: A Rare Presentation in Adults

Pleomorphic Rhabdomyosarcomas (PRMS) in adults are an exceptionally rare and aggressive soft-tissue tumor arising from undifferentiated mesenchymal cells. While more common in children, rhabdomyosarcomas in adults are associated with poorer outcomes and require immediate, aggressive intervention. Here we present a case of high-grade pleomorphic rhabdomyosarcoma of the left thigh in a 58-year-old male with metastases to the lungs and pelvis. Due to the limited diagnostic and treatment protocols of this rare disease and subtype, the goal of this case study is to highlight a comprehensive clinical approach to this disease.