Nueroprotective and Antioxidant Potential of Methanolic and Aqueous Peel Extract of Citrus Sinesis on ?-Amyloid Induced Alzheimers in Mice

This study delves into the intricate pathophysiology of alzheimers disease AD, a leading neurodegenerative disorder characterized by significant neuronal loss and cognitive decline, primarily attributed to oxidative stress. Tracing its roots back to Alois alzheimers discovery in 1906, the research the β-amyloid hypothesis, positing that the accumulation of amyloid plaques plays a pivotal role in AD pathogenesis. These plaques, resulting from the abnormal cleavage of amyloid precursor protein APP, alongside hyperphosphorylated tau proteins, disrupt neuronal function and communication, leading to neurodegeneration and dementia. The paper further investigates the potential therapeutic effects of citrus sinensis peel extract, employing an experimental model to amyloid -induced neurotoxicity. Through a comprehensive analysis involving behavioral and biochemical assessments, including acetylcholinesterase and glutathione estimation, the study aims to elucidate the neuroprotective properties of the extract against AD pathology. This research contributes to the ongoing exploration of natural compounds in migrating alzheimers diseases devastating impact, offering insights into novel treatment avenues grounded in the intricate mechanisms underlying neurodegeneration.