Figure S10 from ERBB4-Mediated Signaling Is a Mediator of Resistance to PI3K and BTK Inhibitors in B-cell Lymphoid Neoplasms

Expression levels of crucial factors are correlated with resistance to idelalisib. HBEGF (A) and ERBB4 (B) expression levels are inversely correlated with idelalisib sensitivity. Conversely expression of let-7c (D) and miR-29c (F) microRNAs is associated with sensitivity to idelalisib. Expression and sensitivity data were analyzed from a previous publication of our group in a panel of 34 B cell lymphoma cell lines (4). Cell lines were split in two groups based on higher or lower values than the median expression of the corresponding gene or miRNA. Mean of idelalisib IC50 were calculated for these two groups and compared by t-test.